WEKO3
アイテム
JunB regulates homeostasis and suppressive functions of effector regulatory T cells
https://oist.repo.nii.ac.jp/records/925
https://oist.repo.nii.ac.jp/records/9255489626d-22b1-4b10-b59d-687e7c3d08d2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Koizumi-2018-JunB regulates homeostasis and su (2.5 MB)
|
Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-10 | |||||
| タイトル | ||||||
| タイトル | JunB regulates homeostasis and suppressive functions of effector regulatory T cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者（英） |
Koizumi, Shin-ichi
× Koizumi, Shin-ichi× Sasaki, Daiki× Hsieh, Tsung-Han× Taira, Naoyuki× Arakaki, Nana× Yamasaki, Shinichi× Wang, Ke× Sarkar, Shukla× Shirahata, Hiroki× Miyagi, Mio× Ishikawa, Hiroki |
|||||
| 書誌情報 |
en : Nature Communications 巻 9, 号 1, p. 5344, 発行日 2018-12-17 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Foxp3-expressing CD4(+) regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells is still unclear. Here we show that the AP-1 transcription factor, JunB, is expressed in eTreg cells and promotes an IRF4-dependent transcription program. Mice lacking JunB in Treg cells develop multi-organ autoimmunity, concomitant with aberrant activation of T helper cells. JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of eTreg. Mechanistically, JunB facilitates the accumulation of IRF4 at a subset of IRF4 target sites, including those located near Icos and Ctla4. Thus, JunB is a critical regulator of IRF4-dependent Treg effector programs, highlighting important functions for AP-1 in Treg-mediated immune homeostasis. | |||||
| 出版者 | ||||||
| 出版者 | Nature Research | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | info:pmid/30559442 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1038/s41467-018-07735-4 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Author(s). | |||||
| 情報源 | ||||||
| 関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-018-07735-4 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
