{"_buckets": {"deposit": "b610dfda-5629-44cd-b686-4413328778e9"}, "_deposit": {"created_by": 28, "id": "925", "owners": [28], "pid": {"revision_id": 0, "type": "depid", "value": "925"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00000925", "sets": ["33", "165"]}, "author_link": ["5019", "5022", "5025", "5018", "5017", "5026", "5024", "5020", "5021", "5023", "5016"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-12-17", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "5344", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{}, {"bibliographic_title": "Nature Communications", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Koizumi, Shin-ichi"}], "nameIdentifiers": [{"nameIdentifier": "5016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Daiki"}], "nameIdentifiers": [{"nameIdentifier": "5017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hsieh, Tsung-Han"}], "nameIdentifiers": [{"nameIdentifier": "5018", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taira, Naoyuki"}], "nameIdentifiers": [{"nameIdentifier": "5019", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arakaki, Nana"}], "nameIdentifiers": [{"nameIdentifier": "5020", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamasaki, Shinichi"}], "nameIdentifiers": [{"nameIdentifier": "5021", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Ke"}], "nameIdentifiers": [{"nameIdentifier": "5022", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sarkar, Shukla"}], "nameIdentifiers": [{"nameIdentifier": "5023", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shirahata, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "5024", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyagi, Mio"}], "nameIdentifiers": [{"nameIdentifier": "5025", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "5026", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "Foxp3-expressing CD4(+) regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells is still unclear. Here we show that the AP-1 transcription factor, JunB, is expressed in eTreg cells and promotes an IRF4-dependent transcription program. Mice lacking JunB in Treg cells develop multi-organ autoimmunity, concomitant with aberrant activation of T helper cells. JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of eTreg. Mechanistically, JunB facilitates the accumulation of IRF4 at a subset of IRF4 target sites, including those located near Icos and Ctla4. Thus, JunB is a critical regulator of IRF4-dependent Treg effector programs, highlighting important functions for AP-1 in Treg-mediated immune homeostasis.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Nature Research"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/30559442", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/s41467-018-07735-4", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_16": {"attribute_name": "情報源", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://creativecommons.org/licenses/by/4.0/"}]}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41467-018-07735-4", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2018 The Author(s)."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-1723", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Koizumi-2018-JunB regulates homeostasis and su.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons\nAttribution 4.0 International​\n(https://creativecommons.org/licenses/by/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "Koizumi-2018-JunB regulates homeostasis and su", "url": "https://oist.repo.nii.ac.jp/record/925/files/Koizumi-2018-JunB regulates homeostasis and su.pdf"}, "version_id": "6960c4b5-7b07-400e-9f79-3536c9faca27"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "JunB regulates homeostasis and suppressive functions of effector regulatory T cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "JunB regulates homeostasis and suppressive functions of effector regulatory T cells", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "28", "path": ["33", "165"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/925", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-06-10"}, "publish_date": "2019-06-10", "publish_status": "0", "recid": "925", "relation": {}, "relation_version_is_last": true, "title": ["JunB regulates homeostasis and suppressive functions of effector regulatory T cells"], "weko_shared_id": 28}