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JunB regulates homeostasis and suppressive functions of effector regulatory T cells
https://oist.repo.nii.ac.jp/records/925
https://oist.repo.nii.ac.jp/records/9255489626d-22b1-4b10-b59d-687e7c3d08d2
名前 / ファイル | ライセンス | アクション |
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Koizumi-2018-JunB regulates homeostasis and su (2.5 MB)
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Creative Commons
Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-06-10 | |||||
タイトル | ||||||
タイトル | JunB regulates homeostasis and suppressive functions of effector regulatory T cells | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Koizumi, Shin-ichi
× Koizumi, Shin-ichi× Sasaki, Daiki× Hsieh, Tsung-Han× Taira, Naoyuki× Arakaki, Nana× Yamasaki, Shinichi× Wang, Ke× Sarkar, Shukla× Shirahata, Hiroki× Miyagi, Mio× Ishikawa, Hiroki |
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書誌情報 |
en : Nature Communications 巻 9, 号 1, p. 5344, 発行日 2018-12-17 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Foxp3-expressing CD4(+) regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells is still unclear. Here we show that the AP-1 transcription factor, JunB, is expressed in eTreg cells and promotes an IRF4-dependent transcription program. Mice lacking JunB in Treg cells develop multi-organ autoimmunity, concomitant with aberrant activation of T helper cells. JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of eTreg. Mechanistically, JunB facilitates the accumulation of IRF4 at a subset of IRF4 target sites, including those located near Icos and Ctla4. Thus, JunB is a critical regulator of IRF4-dependent Treg effector programs, highlighting important functions for AP-1 in Treg-mediated immune homeostasis. | |||||
出版者 | ||||||
出版者 | Nature Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
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関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30559442 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/s41467-018-07735-4 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by/4.0/ | |||||
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識別子タイプ | URI | |||||
関連識別子 | https://www.nature.com/articles/s41467-018-07735-4 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |