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Whole Blood Metabolomics in Aging Research
https://oist.repo.nii.ac.jp/records/1921
https://oist.repo.nii.ac.jp/records/1921bde73e44-2cb6-499a-8b90-db4190eb9c17
名前 / ファイル | ライセンス | アクション |
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Kondoh-2021-Whole Blood Metabolomics in Aging (1.5 MB)
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Creative Commons Attribution 4.0 International(https://creativecommons.org/licenses/by/4.0/)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-05 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Whole Blood Metabolomics in Aging Research | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aging | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | metabolites | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | frailty | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | fasting | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | antioxidant | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | metabolomics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | whole blood | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Kondoh, Hiroshi
× Kondoh, Hiroshi× Kameda, Masahiro× Yanagida, Mitsuhiro |
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書誌情報 |
en : International Journal of Molecular Sciences 巻 22, 号 1, p. 175, 発行日 2020-12-26 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Diversity is observed in the wave of global aging because it is a complex biological process exhibiting individual variability. To assess aging physiologically, markers for biological aging are required in addition to the calendar age. From a metabolic perspective, the aging hypothesis includes the mitochondrial hypothesis and the calorie restriction (CR) hypothesis. In experimental models, several compounds or metabolites exert similar lifespan-extending effects, like CR. However, little is known about whether these metabolic modulations are applicable to human longevity, as human aging is greatly affected by a variety of factors, including lifestyle, genetic or epigenetic factors, exposure to stress, diet, and social environment. A comprehensive analysis of the human blood metabolome captures complex changes with individual differences. Moreover, a non-targeted analysis of the whole blood metabolome discloses unexpected aspects of human biology. By using such approaches, markers for aging or aging-relevant conditions were identified. This information should prove valuable for future diagnosis or clinical interventions in diseases relevant to aging. | |||||
出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1422-0067 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1661-6596 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/33375345 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3390/ijms22010175 | |||||
権利 | ||||||
権利情報 | © 2020 The Author(s). | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://www.mdpi.com/1422-0067/22/1/175 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |