{"_buckets": {"deposit": "d673d06f-f258-4724-90fb-7f83e7f63314"}, "_deposit": {"created_by": 28, "id": "1981", "owners": [28], "pid": {"revision_id": 0, "type": "depid", "value": "1981"}, "status": "published"}, "_oai": {"id": "oai:oist.repo.nii.ac.jp:00001981", "sets": ["33", "67", "167"]}, "author_link": ["12985", "12977", "12986", "12982", "12978", "12984", "12988", "12987", "12976", "12989", "12983", "12979", "12980", "12981"], "item_10001_biblio_info_7": {"attribute_name": "Bibliographic Information", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-12-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "6169", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{}, {"bibliographic_title": "Nature Communications", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "Author", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ito-Kureha, Taku"}], "nameIdentifiers": [{"nameIdentifier": "12976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyao, Takahisa"}], "nameIdentifiers": [{"nameIdentifier": "12977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishijima, Saori"}], "nameIdentifiers": [{"nameIdentifier": "12978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Toru"}], "nameIdentifiers": [{"nameIdentifier": "12979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koizumi, Shin-ichi"}], "nameIdentifiers": [{"nameIdentifier": "12980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Villar-Briones, Alejandro"}], "nameIdentifiers": [{"nameIdentifier": "12981", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Akinori"}], "nameIdentifiers": [{"nameIdentifier": "12982", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akiyama, Nobuko"}], "nameIdentifiers": [{"nameIdentifier": "12983", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "12984", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naguro, Isao"}], "nameIdentifiers": [{"nameIdentifier": "12985", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "12986", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichijo, Hidenori"}], "nameIdentifiers": [{"nameIdentifier": "12987", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akiyama, Taishin"}], "nameIdentifiers": [{"nameIdentifier": "12988", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "12989", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "Abstract", "attribute_value_mlt": [{"subitem_description": "A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are not clear. Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly(A) tails, enabling positive selection. Specifically, the CCR4-NOT complex is up-regulated in thymocytes before initiation of positive selection, where in turn, it inhibits up-regulation of pro-apoptotic Bbc3 and Dab2ip. Elimination of the CCR4-NOT complex permits up-regulation of Bbc3 during a later stage of positive selection, inducing thymocyte apoptosis. In addition, CCR4-NOT elimination up-regulates Dab2ip at an early stage of positive selection. Thus, CCR4-NOT might control thymocyte survival during two-distinct stages of positive selection by suppressing expression levels of pro-apoptotic molecules. Taken together, we propose a link between CCR4-NOT-mediated mRNA decay and T cell selection in the thymus.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "Publisher", "attribute_value_mlt": [{"subitem_publisher": "Nature Research"}]}, "item_10001_relation_13": {"attribute_name": "PubMedNo.", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:pmid/33268794", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/s41467-020-19975-4", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "Related site", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41467-020-19975-4", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "Rights", "attribute_value_mlt": [{"subitem_rights": "© 2020 The Author(s)."}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-1723", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "Author\u0027s flag", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-03-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Ito-Kureha-2020-The CCR4-NOT deadenylase compl.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/)", "licensetype": "license_free", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "Ito-Kureha-2020-The CCR4-NOT deadenylase compl", "url": "https://oist.repo.nii.ac.jp/record/1981/files/Ito-Kureha-2020-The CCR4-NOT deadenylase compl.pdf"}, "version_id": "d0a02353-deaf-45d7-806f-833a13c7909e"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "28", "path": ["33", "67", "167"], "permalink_uri": "https://oist.repo.nii.ac.jp/records/1981", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-03-17"}, "publish_date": "2021-03-17", "publish_status": "0", "recid": "1981", "relation": {}, "relation_version_is_last": true, "title": ["The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression"], "weko_shared_id": 28}