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Ramping activity in the striatum
https://oist.repo.nii.ac.jp/records/2807
https://oist.repo.nii.ac.jp/records/28072f638025-c8e5-4b86-9012-6ddfc09a8ec9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
fncom-16-902741 (2.4 MB)
|
CC BY 4.0
Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2022-10-04 | |||||||||
| タイトル | ||||||||||
| タイトル | Ramping activity in the striatum | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | interval discrimination | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | computational model | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | striatum | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | basal ganglia | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | neural ramping | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | network dynamics | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | temporal estimation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者（英） |
Ponzi, Adam
× Ponzi, Adam
× Wickens, Jeff
|
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| 書誌情報 |
en : Frontiers in Computational Neuroscience 巻 16, 発行日 2022-08-01 |
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| 抄録 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Control of the timing of behavior is thought to require the basal ganglia (BG) and BG pathologies impair performance in timing tasks. Temporal interval discrimination depends on the ramping activity of medium spiny neurons (MSN) in the main BG input structure, the striatum, but the underlying mechanisms driving this activity are unclear. Here, we combine an MSN dynamical network model with an action selection system applied to an interval discrimination task. We find that when network parameters are appropriate for the striatum so that slowly fluctuating marginally stable dynamics are intrinsically generated, up and down ramping populations naturally emerge which enable significantly above chance task performance. We show that emergent population activity is in very good agreement with empirical studies and discuss how MSN network dysfunction in disease may alter temporal perception. | |||||||||
| 出版者 | ||||||||||
| 出版者 | Frontiers Media | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1662-5188 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | info:pmid/35978564 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | info:doi/10.3389/fncom.2022.902741 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2022 The Author(s). | |||||||||
| 権利 | ||||||||||
| 権利情報 | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.frontiersin.org/articles/10.3389/fncom.2022.902741/full | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
