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Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect)
https://oist.repo.nii.ac.jp/records/875
https://oist.repo.nii.ac.jp/records/875a053d397-94c8-4049-a2b4-c6d82edc9711
名前 / ファイル | ライセンス | アクション |
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Wang-2018-Increased Hematopoietic Stem Cells_H (380.4 kB)
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Creative Commons
Attribution 4.0 International (http://www.creativecommons.org/licenses/by-nc/4.0/) |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-05-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Increased Hematopoietic Stem Cells/Hematopoietic Progenitor Cells Measured as Endogenous Spleen Colonies in Radiation-Induced Adaptive Response in Mice (Yonezawa Effect) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者(英) |
Wang, Bing
× Wang, Bing× Tanaka, Kaoru× Ninomiya, Yasuharu× Maruyama, Kouichi× Varès, Guillaume× Katsube, Takanori× Murakami, Masahiro× Liu, Cuihua× Fujimori, Akira× Fujita, Kazuko× Liu, Qiang× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru |
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書誌情報 |
en : Dose-Response 巻 16, 号 3, p. 1559325818790152, 発行日 2018-08-20 |
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抄録 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming radiation-induced resistance in the blood-forming tissues. In a series of investigations, we further demonstrated the existence of AR using different types of ionizing radiation (IR) including low linear energy transfer (LET) X-rays and high LET heavy ion. In this article, we validated hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony-forming units-spleen (CFU-S) under AR inducible and uninducible conditions using combination of different types of IR. We confirmed the consistency of increased CFU-S number change with the AR inducible condition. These findings suggest that AR in mice induced by different types of IR would share at least in part a common underlying mechanism, the priming IR-induced resistance in the blood-forming tissues, which would lead to a protective effect on the HSCs/HPCs and play an important role in rescuing the animals from bone marrow death. These findings provide a new insight into the mechanistic study on AR in vivo. | |||||
出版者 | ||||||
出版者 | SAGE Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1559-3258 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | info:pmid/30150909 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1177/1559325818790152 | |||||
権利 | ||||||
権利情報 | © 2018 The Author(s). | |||||
情報源 | ||||||
関連名称 | https://creativecommons.org/licenses/by-nc/4.0/ | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://journals.sagepub.com/doi/10.1177/1559325818790152 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |